I can’t believe I actually lived though the full transition from VHS to DVD. Like there are people alive who have never seen a VHS tape….I remember when we were still tryna figure out how the fuck they got a full movie onto a cd.
Gabriel Vick celebrates at the press night afterparty for his new musical Miss Atomic Bomb last night, with his wife Kerry Howard and the show’s co-director and choreographer Bill Deamer.
I have to stop saying, ‘How am I going to kill myself out of this one?’ every time there is trouble going on, or at least not out loud.
a new hope was a great movie
Suzanne Sadedin, Ph.D. in evolutionary biology from Monash University
I’m so glad you asked. Seriously. The answer to this question is one of the most illuminating and disturbing stories in human evolutionary biology, and almost nobody knows about it. And so, O my friends, gather close, and hear the extraordinary tale of:
HOW THE WOMAN GOT HER PERIOD
Contrary to popular belief, most mammals do not menstruate. In fact, it’s a feature exclusive to the higher primates and certain bats*. What’s more, modern women menstruate vastly more than any other animal. And it’s bloody stupid (sorry). A shameful waste of nutrients, disabling, and a dead giveaway to any nearby predators. To understand why we do it, you must first understand that you have been lied to, throughout your life, about the most intimate relationship you will ever experience: the mother-fetus bond.
Isn’t pregnancy beautiful? Look at any book about it. There’s the future mother, one hand resting gently on her belly. Her eyes misty with love and wonder. You sense she will do anything to nurture and protect this baby. And when you flip open the book, you read about more about this glorious symbiosis, the absolute altruism of female physiology designing a perfect environment for the growth of her child.
If you’ve actually been pregnant, you might know that the real story has some wrinkles. Those moments of sheer unadulterated altruism exist, but they’re interspersed with weeks or months of overwhelming nausea, exhaustion, crippling backache, incontinence, blood pressure issues and anxiety that you’ll be among the 15% of women who experience life-threatening complications.
From the perspective of most mammals, this is just crazy. Most mammals sail through pregnancy quite cheerfully, dodging predators and catching prey, even if they’re delivering litters of 12. So what makes us so special? The answer lies in our bizarre placenta. In most mammals, the placenta, which is part of the fetus, just interfaces with the surface of the mother’s blood vessels, allowing nutrients to cross to the little darling. Marsupials don’t even let their fetuses get to the blood: they merely secrete a sort of milk through the uterine wall. Only a few mammalian groups, including primates and mice, have evolved what is known as a “hemochorial” placenta, and ours is possibly the nastiest of all.
Inside the uterus we have a thick layer of endometrial tissue, which contains only tiny blood vessels. The endometrium seals off our main blood supply from the newly implanted embryo. The growing placenta literally burrows through this layer, rips into arterial walls and re-wires them to channel blood straight to the hungry embryo. It delves deep into the surrounding tissues, razes them and pumps the arteries full of hormones so they expand into the space created. It paralyzes these arteries so the mother cannot even constrict them.
What this means is that the growing fetus now has direct, unrestricted access to its mother’s blood supply. It can manufacture hormones and use them to manipulate her. It can, for instance, increase her blood sugar, dilate her arteries, and inflate her blood pressure to provide itself with more nutrients. And it does. Some fetal cells find their way through the placenta and into the mother’s bloodstream. They will grow in her blood and organs, and even in her brain, for the rest of her life, making her a genetic chimera**.
This might seem rather disrespectful. In fact, it’s sibling rivalry at its evolutionary best. You see, mother and fetus have quite distinct evolutionary interests. The mother ‘wants’ to dedicate approximately equal resources to all her surviving children, including possible future children, and none to those who will die. The fetus ‘wants’ to survive, and take as much as it can get. (The quotes are to indicate that this isn’t about what they consciously want, but about what evolution tends to optimize.)
There’s also a third player here – the father, whose interests align still less with the mother’s because her other offspring may not be his. Through a process called genomic imprinting, certain fetal genes inherited from the father can activate in the placenta. These genes ruthlessly promote the welfare of the offspring at the mother’s expense.
How did we come to acquire this ravenous hemochorial placenta which gives our fetuses and their fathers such unusual power? Whilst we can see some trend toward increasingly invasive placentae within primates, the full answer is lost in the mists of time. Uteri do not fossilize well.
The consequences, however, are clear. Normal mammalian pregnancy is a well-ordered affair because the mother is a despot. Her offspring live or die at her will; she controls their nutrient supply, and she can expel or reabsorb them any time. Human pregnancy, on the other hand, is run by committee – and not just any committee, but one whose members often have very different, competing interests and share only partial information. It’s a tug-of-war that not infrequently deteriorates to a tussle and, occasionally, to outright warfare. Many potentially lethal disorders, such as ectopic pregnancy, gestational diabetes, and pre-eclampsia can be traced to mis-steps in this intimate game.
What does all this have to do with menstruation? We’re getting there.
From a female perspective, pregnancy is always a huge investment. Even more so if her species has a hemochorial placenta. Once that placenta is in place, she not only loses full control of her own hormones, she also risks hemorrhage when it comes out. So it makes sense that females want to screen embryos very, very carefully. Going through pregnancy with a weak, inviable or even sub-par fetus isn’t worth it.
That’s where the endometrium comes in. You’ve probably read about how the endometrium is this snuggly, welcoming environment just waiting to enfold the delicate young embryo in its nurturing embrace. In fact, it’s quite the reverse. Researchers, bless their curious little hearts, have tried to implant embryos all over the bodies of mice. The single most difficult place for them to grow was – the endometrium.
Far from offering a nurturing embrace, the endometrium is a lethal testing-ground which only the toughest embryos survive. The longer the female can delay that placenta reaching her bloodstream, the longer she has to decide if she wants to dispose of this embryo without significant cost. The embryo, in contrast, wants to implant its placenta as quickly as possible, both to obtain access to its mother’s rich blood, and to increase her stake in its survival. For this reason, the endometrium got thicker and tougher – and the fetal placenta got correspondingly more aggressive.
But this development posed a further problem: what to do when the embryo died or was stuck half-alive in the uterus? The blood supply to the endometrial surface must be restricted, or the embryo would simply attach the placenta there. But restricting the blood supply makes the tissue weakly responsive to hormonal signals from the mother – and potentially more responsive to signals from nearby embryos, who naturally would like to persuade the endometrium to be more friendly. In addition, this makes it vulnerable to infection, especially when it already contains dead and dying tissues.
The solution, for higher primates, was to slough off the whole superficial endometrium – dying embryos and all – after every ovulation that didn’t result in a healthy pregnancy. It’s not exactly brilliant, but it works, and most importantly, it’s easily achieved by making some alterations to a chemical pathway normally used by the fetus during pregnancy. In other words, it’s just the kind of effect natural selection is renowned for: odd, hackish solutions that work to solve proximate problems. It’s not quite as bad as it seems, because in nature, women would experience periods quite rarely – probably no more than a few tens of times in their lives between lactational amenorrhea and pregnancies***.
We don’t really know how our hyper-aggressive placenta is linked to the other traits that combine to make humanity unique. But these traits did emerge together somehow, and that means in some sense the ancients were perhaps right. When we metaphorically ‘ate the fruit of knowledge’ – when we began our journey toward science and technology that would separate us from innocent animals and also lead to our peculiar sense of sexual morality – perhaps that was the same time the unique suffering of menstruation, pregnancy and childbirth was inflicted on women. All thanks to the evolution of the hemochorial placenta.
This is so bad-ass and yet also the worst.
“Researchers, bless their curious little hearts, have tried to implant embryos all over the bodies of mice.”
Can I just say, uh, I’m pretty sure noticing you’re asexual is harder than noticing you’re gay, straight, pan or otherwise. Like, I just read someone’s desciption of hitting puberty and, like, there’s nothing like that. There’s no sudden ‘boob’ moment, no sudden ‘fuck, I’d fuck that’ moment, not sudden anything. You just, like, plod on through life as usual going ‘oooh, that’s pretty, I’d like that hair’ or ‘oooooh, they’re nice, I’d like to be close to them’ but there’s no like, ‘oh, someone would want to fuck that but I don’t’, you know? You just- you don’t notice, you don’t realise everyone else has ‘had a moment’ but you haven’t, you just- keep going as you always have.
And then, much much later, you start to wonder why people are getting so caught up in drama for romance or sex, like, why bother? It’s not worth it, they’re not worth it, why are you doing stupid things for something that’s so- and then you wonder if there’s something wrong with you, start mentally over compensating. Like ‘uh, okay, um, who should I date? Who can I stand to date? Who could I stand to fuck?’ like- it’s not, it’s not something you want, but you want to fit in, to be normal.
Sometimes you don’t even know that you’re doing it.
Sometimes you don’t even know asexual’s a thing.
I dunno, I guess, I just feel like, uh, people should understand more?
idk sorry thank you for listening to me
Thank you for perfectly describing it.
BoyMan of the Republic or Anakin’s Jedi attire in ROTS
(+the way he wears it)
OK. I had given up going to sleep in favor of finishing watching Jack the Giant Slayer and… I picked up a crack/rarepair. BECAUSE I REALLY NEEDED ONE OF THOSE FOR A MOVIE THAT’S ALREADY YULETIDE-LEVEL SMALL. *headdesk* DAMN it. -.-;;; And damn Elmont and the King for throwing all those Looks at each other during the final battle. UGH, YOU TWO. HONESTLY. I DIDN’T ASK FOR THIS. *sobs softly*
*turns off dead poets society immediately after Neil’s play is over*
What a lovely ending 🙂